M. A. Horton

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo.

V. Wayne Engleman, G. Allen Nickols, F. Patrick Ross et al. · Journal of Clinical Investigation · 1997 · 287 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Single Integrin Molecule Adhesion Forces in Intact Cells Measured by Atomic Force Microscopy

Petri Lehenkari, M. A. Horton · Biochemical and Biophysical Research Communications · 1999 · 286 citations

Life Sciences, Biophysics, Cell Biology +16

ArgGlyAsp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts*1

M. A. Horton · Experimental Cell Research · 1991 · 245 citations

Dentistry, Oral Biology, Dentin Biology +6

Vitronectin receptor has a role in bone resorption but does not mediate tight sealing zone attachment of osteoclasts to the bone surface.

Päivi T. Lakkakorpi, M. A. Horton, Miep Helfrich et al. · The Journal of Cell Biology · 1991 · 169 citations · Full text

Medicine, Cell Biology, Bone Metabolism +16

Biochemical characterization of human osteoclast integrins. Osteoclasts express alpha v beta 3, alpha 2 beta 1, and alpha v beta 1 integrins

Stephen A. Nesbitt, April D. Nesbit, Miep Helfrich et al. · Journal of Biological Chemistry · 1993 · 164 citations · Full text

Medicine, Cell Biology, Bone Metabolism +7