CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

Fathia Djelti, Jérôme Braudeau, Eloïse Hudry, +16

Brain

Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates

Fabien Pifferi, Jérémy Terrien, Julia Marchal, +16

Communications Biology

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

Marie-Anne Burlot, Jérôme Braudeau, Kristin Michaelsen‐Preusse, +18

Human Molecular Genetics

Alzheimer-like Tau PathologyMemory ImpairmentsAlzheimer's DiseaseDegenerative PathologyNeurology +16

Regulatory and Effector T Cell Activation Levels Are Prime Determinants of In Vivo Immune Regulation

Fabienne Billiard, David Saadoun, Fathia Djelti, +4

The Journal of Immunology

Therapeutic potential of self‐antigen‐specific CD4⁺CD25⁺ regulatory T cells selected <i>in vitro</i> from a polyclonal repertoire

Sylvain Fisson, Fathia Djelti, Aurélie Trenado, +5

European Journal of Immunology

Therapeutic PotentialAdaptive Immune SystemT-regulatory CellImmunologyImmune Regulation +18

Deficits of psychomotor and mnesic functions across aging in mouse lemur primates

Solà ̈ne Languille, Agatha Liévin-Bazin, Jean‐Luc Picq, +9

Frontiers in Behavioral Neuroscience

Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus

Farah Chali, Fathia Djelti, Emmanuel Eugène, +7

European Journal of Neuroscience

Cell DeathSocial SciencesAlzheimer's DiseaseDegenerative PathologyNeurology +16

Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates

Fathia Djelti, Marc Dhénain, Jérémy Terrien, +7

Aging

Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis

Sophie Ayciriex, Fathia Djelti, Sandro Alves, +11

Frontiers in Molecular Neuroscience