Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor

Zhenlin Yang, Shuo Han, Max Keller, +23

Nature

BiochemistryG Protein-coupled ReceptorProtein FoldingNatural SciencesReceptor (Biochemistry) +8

Acylguanidines as Bioisosteres of Guanidines:<i>N</i>^G-Acylated Imidazolylpropylguanidines, a New Class of Histamine H₂Receptor Agonists

Prasanta Ghorai, Anja Kraus, Max Keller, +10

Journal of Medicinal Chemistry

Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors

Tingting Tang, Qiuxiang Tan, Shuo Han, +16

Science Advances

Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors

Ulrich Gergs, G. Bernhardt, Igor Buchwalow, +8

Journal of Pharmacology and Experimental Therapeutics

G protein-coupled receptors function as logic gates for nanoparticle binding and cell uptake

Wolfgang Hild, Klaus Pollinger, Andrea Caporale, +7

Proceedings of the National Academy of Sciences

NanoparticlesAntagonist-modified NanoparticlesNanotherapeuticsEngineeringPeptide Science +20

Synthesis and Characterization of the First Fluorescent Nonpeptide NPY Y₁ Receptor Antagonist

Erich Schneider, Max Keller, Albert Brennauer, +5

ChemBioChem

Guanidine−Acylguanidine Bioisosteric Approach in the Design of Radioligands: Synthesis of a Tritium-Labeled<i>N</i>^G-Propionylargininamide ([³H]-UR-MK114) as a Highly Potent and Selective Neuropeptide Y Y₁Receptor Antagonist

Max Keller, Nathalie Pop, Christoph Hutzler, +3

Journal of Medicinal Chemistry

Mimicking of Arginine by Functionalized<i>N</i>^ω-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples

Max Keller, Kilian Kuhn, Jürgen Einsiedel, +10

Journal of Medicinal Chemistry

Red-fluorescent argininamide-type NPY Y1 receptor antagonists as pharmacological tools

Max Keller, Daniela Erdmann, Nathalie Pop, +4

Bioorganic & Medicinal Chemistry

Molecular PharmacologyFunctional SelectivityMedicineReceptor (Biochemistry)Neuropeptide Receptor +4

NG-Acyl-argininamides as NPY Y1 receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity

Max Keller, Günther Bernhardt, Armin Buschauer, +1

Bioorganic & Medicinal Chemistry

BiochemistryFunctional SelectivityDiverse Acyl SubstituentsMedicineReceptor (Biochemistry) +6