RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation

Homa Rahnamoun, Ji Hoon Lee, Zhengxi Sun, +4

Nature Structural & Molecular Biology

ChromatinTranscriptional RegulationEnhanced Chromatin EngagementChromatin RemodelingNatural Sciences +10

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

Changwei Peng, Matthew A. Huggins, Kelsey M. Wanhainen, +10

Immunity

Signal TransductionCostimulatory Molecule IcosImmunologyAutoimmunityT Cell Immunity +6

Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

Homa Rahnamoun, Hanbin Lu, Sascha H. Duttke, +3

Nature Communications

Calcium signaling instructs NIPBL recruitment at active enhancers and promoters via distinct mechanisms to reconstruct genome compartmentalization

Yina Zhu, Matthew Denholtz, Hanbin Lu, +1

Genes & Development

A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

E. Mauricio Barajas-Mora, Eden Kleiman, Jeffrey Xu, +5

Molecular Cell

Signal TransductionLymphocyte DevelopmentImmune Cell DevelopmentAdaptive Immune SystemImmunology +7

Upon microbial challenge, human neutrophils undergo rapid changes in nuclear architecture and chromatin folding to orchestrate an immediate inflammatory gene program

Matthew Denholtz, Yina Zhu, Zhaoren He, +5

Genes & Development

InflammationChromatinTranscriptional RegulationChromatin RemodelingGranulocyte +13

Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4

Homa Rahnamoun, Juyeong Hong, Zhengxi Sun, +3

Journal of Biological Chemistry

Nuclear morphology is shaped by loop-extrusion programs

Indumathi Patta, Maryam Zand, Lindsay Lee, +11

Nature

EngineeringNuclear MorphologyMolecular BiologyNucleationCrystallography +1

Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens

E. Mauricio Barajas-Mora, Lindsay Lee, Hanbin Lu, +6

Nature Immunology

Enhancer-instructed Epigenetic LandscapeMicrobial PathogensChromatin CompartmentalizationMedicineVirulence Factor +11

Transcriptome-Wide Analysis Reveals the Origin of Peloria in Chinese Cymbidium (Cymbidium sinense)

Shihao Su, Xiaoyu Shao, Changfa Zhu, +9

Plant and Cell Physiology

BotanyGeneticsMolecular GeneticsFloral MorphogenesisGenomics +21