A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

Yoshikane Kikushige, Toshihiro Miyamoto, Junichiro Yuda, +9

Cell stem cell

Hematological MalignancyCell TherapyMixed-phenotype Acute LeukemiaMyeloid NeoplasiaLeukemic Progression +4

Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets

Kennosuke Karube, Anna Enjuanes, Iván Dlouhy, +36

Leukemia

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer

Michitaka Nakano, Yoshikane Kikushige, Kohta Miyawaki, +12

Oncogene

Tumor BiologyLineage PlasticityDevelopmental BiologyMedicineDedifferentiation Process +10

M2 Macrophages Enhance Pathological Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy

Yedi Zhou, Shigeo Yoshida, Shintaro Nakao, +10

Investigative Ophthalmology & Visual Science

Anti-GPRC5D/CD3 Bispecific T-Cell–Redirecting Antibody for the Treatment of Multiple Myeloma

Tatsushi Kodama, Yu Kochi, Waka Nakai, +12

Molecular Cancer Therapeutics

Identification of unipotent megakaryocyte progenitors in human hematopoiesis

Kohta Miyawaki, Hiromi Iwasaki, Takashi Jiromaru, +17

Blood

Contribution of Bone Marrow-Derived Hematopoietic Stem/Progenitor Cells to the Generation of Donor-Marker+ Cardiomyocytes In Vivo

Mitsuhiro Fukata, Fumihiko Ishikawa, Yuho Najima, +12

PLoS ONE

Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease

Takeshi Sugio, Koji Kato, Takatoshi Aoki, +23

Biology of Blood and Marrow Transplantation

CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines

Ayako Takaki-Kuwahara, Yojiro Arinobu, Kohta Miyawaki, +11

Arthritis Research & Therapy

Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non–small cell lung cancer

Noriko Hidaka, Eiji Iwama, Naoki Kubo, +8

Lung Cancer

Tumor BiologyCell Lung CancerMedicinePathologyCancer Genomics +9