A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1

Panfeng Tao, Jinqiao Sun, Zheming Wu, +33

Nature

InflammationAutoimmune DiseaseAutoantibody ProductionDisease MechanismMedicine +11

Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design

Yusha Wang, Jun Wang, Wenjie Zheng, +10

Immunity

InflammationIl-1-targeted Drug DesignCytokineAutoimmune DiseaseImmunology +7

Identification of HIF-1 signaling pathway in Pelteobagrus vachelli using RNA-Seq: effects of acute hypoxia and reoxygenation on oxygen sensors, respiratory metabolism, and hematology indices

Guosong Zhang, Cheng Zhao, Qintao Wang, +5

Journal of Comparative Physiology B

BiologyPelteobagrus VachelliRedox RegulatorNatural SciencesGenetics +9

Oligomerization-primed coiled-coil domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity

Lin Hu, Jiafeng Xu, Xiaomei Xie, +9

Nature Communications

Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production

Panfeng Tao, Shihao Wang, Seza Özen, +13

Science Advances

A gain-of-function variation in PLCG1 causes a new immune dysregulation disease

Panfeng Tao, Xu Han, Qintao Wang, +10

Journal of Allergy and Clinical Immunology

Gain-of-function VariationImmunogeneticsAutoimmune DiseaseImmune Cell DevelopmentImmune Regulation +8

Haploinsufficiency of PSMD12 Causes Proteasome Dysfunction and Subclinical Autoinflammation

Kai Yan, Jiahui Zhang, Pui Y. Lee, +5

Arthritis & Rheumatology

A Cohort Study on Deficiency of ADA2 from China

Guomin Li, Xu Han, Ye Wu, +40

Journal of Clinical Immunology

Somatic gain-of-function mutation in TLR7 causes early-onset systemic lupus erythematosus

Yi Zeng, Panfeng Tao, Jun Wang, +10

Annals of the Rheumatic Diseases

Linear ubiquitination regulates the KSHV replication and transcription activator protein to control infection

Yi Luan, Wenying Long, Lisi Dai, +3

Nature Communications