Effects of FK228, a novel histone deacetylase inhibitor, on human lymphoma U-937 cells in vitro and in vivo

Yuka Sasakawa, Yoshinori Naoe, Takeshi Inoue, +4

Biochemical Pharmacology

Tumor BiologyLymphoid NeoplasiaMedicinePathologyCancer Biology +4

Atopic Dermatitis-Like Skin Lesions Induced by Topical Application of Mite Antigens in NC/Nga Mice

Tatsuya Sasakawa, Yasuyuki Higashi, Syozo Sakuma, +6

International Archives of Allergy and Immunology

Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors

Yuka Sasakawa, Yoshinori Naoe, Takahisa Noto, +5

Biochemical Pharmacology

Marker genes to predict sensitivity to FK228, a histone deacetylase inhibitor

Yuka Sasakawa, Yoshinori Naoe, Naoki Sogo, +5

Biochemical Pharmacology

Histone ModificationsChromatinHistone Deacetylase InhibitorChromatin RemodelingMedicine +10

Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and expression of p21 and c-myc genes in vivo

Yuka Sasakawa, Yoshinori Naoe, Takeshi Inoue, +4

Cancer Letters

Histone ModificationsChromatinMedicineTumor GrowthC-myc Genes +10

FK506 suppresses neutrophil chemoattractant production by peripheral blood mononuclear cells

Yuka Sasakawa, Shozo Sakuma, Yasuyuki Higashi, +3

European Journal of Pharmacology

InflammationCytokineGranulocyteImmunologyImmune Regulation +7

FK506 suppresses E-selectin, ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor necrosis factor α secretion from peripheral blood mononuclear cells

Tatsuya Sasakawa, Yuka Sasakawa, Taro Masunaga, +4

Cytokine

InflammationEndothelial Cell PathobiologyCytokineMolecular PhysiologyVcam-1 Expression +12

FK506 ameliorates spontaneous locomotor activity in collagen-induced arthritis: implication of distinct effect from suppression of inflammation

Tatsuya Sasakawa, Yuka Sasakawa, Y. Ohkubo, +1

International Immunopharmacology

InflammationRheumatologyMechanobiologyMusculoskeletal ResearchKinesiology +11

Topical Application of FK506 (Tacrolimus) Ointment Inhibits Mite Antigen-Induced Dermatitis by Local Action in NC/Nga Mice

Tatsuya Sasakawa, Yasuyuki Higashi, Shozo Sakuma, +4

International Archives of Allergy and Immunology

Anti-diabetic effects of globin digest and its active ingredient Leu-Ser-Glu-Leu in ICR mice, streptozotocin-induced diabetic mice and KK-Ay mice

Fumiko Nakaoka, Yuka Sasakawa, Kaori Yamamoto, +5

Life Sciences

Metabolic SyndromeGlobin DigestMedicineInsulin ManagementPhysiology +7