Construction of Drug–Polymer Thermodynamic Phase Diagrams Using Flory–Huggins Interaction Theory: Identifying the Relevance of Temperature and Drug Weight Fraction to Phase Separation within Solid Dispersions

Yiwei Tian, Jonathan Booth, E. J. Meehan, +3

Molecular Pharmaceutics

Phase DiagramsPharmaceutical ScienceEngineeringSolid DispersionsChemistry +22

Comparative Study of Different Methods for the Prediction of Drug–Polymer Solubility

Matthias Manne Knopp, Lidia Tajber, Yiwei Tian, +10

Molecular Pharmaceutics

Pharmaceutical ScienceMacromolecular ChemistryEngineeringDrug–polymer SolubilityChemistry +21

Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Feasibility Studies and Physicochemical Characterization

Shu Li, Tao Yu, Yiwei Tian, +3

Molecular Pharmaceutics

EngineeringMechanical EngineeringPharmaceutical Cocrystal SuspensionsChemistryPharmaceutical Technology +15

The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform

Yiwei Tian, Esther Jacobs, David S. Jones, +3

International Journal of Pharmaceutics

Materials ScienceHigh DrugEngineeringMechanical EngineeringHot-melt Extrusion Platform +6

Using Flory–Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying

Yiwei Tian, Vincent Caron, David S. Jones, +2

Journal of Pharmacy and Pharmacology

Optimising Drug Solubilisation in Amorphous Polymer Dispersions: Rational Selection of Hot-melt Extrusion Processing Parameters

Shu Li, Yiwei Tian, David S. Jones, +1

AAPS PharmSciTech

Materials ScienceRational SelectionDrug SolubilisationAmorphous Polymer DispersionsEngineering +9

Probing the Effects of Experimental Conditions on the Character of Drug-Polymer Phase Diagrams Constructed Using Flory-Huggins Theory

Conor Donnelly, Yiwei Tian, Catherine B. Potter, +2

Pharmaceutical Research

Polymer ChemistryEngineeringMacromolecular ArchitecturePolymer SolutionPolymer Science +7

Novel Supercritical Carbon Dioxide Impregnation Technique for the Production of Amorphous Solid Drug Dispersions: A Comparison to Hot Melt Extrusion

Catherine B. Potter, Yiwei Tian, Gavin Walker, +5

Molecular Pharmaceutics

Materials ScienceEngineeringOrganic SolventsSupercritical Co2Supercritical Fluid Chromatography +10

An Investigation into the Role of Polymeric Carriers on Crystal Growth within Amorphous Solid Dispersion Systems

Yiwei Tian, David S. Jones, Gavin P. Andrews

Molecular Pharmaceutics

Macromolecular ChemistryEngineeringChemistrySoft MatterPolymers +15

A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products

Jeremiah Kelleher, Gareth C. Gilvary, Atif Madi, +7

International Journal of Pharmaceutics

HypertensionHot-melt ExtrusionBiomedical EngineeringMedicineComparative Study