Prolonged abstinence from developmental cocaine exposure dysregulates BDNF and its signaling network in the medial prefrontal cortex of adult rats

Giuseppe Giannotti, Lucia Caffino, Francesca Calabrese, +3

The International Journal of Neuropsychopharmacology

Behavioral AddictionSignaling NetworkNeurotransmitterSocial SciencesPsychology +20

Region-specific effects on BDNF expression after contingent or non-contingent cocaine i.v. self-administration in rats

Fabio Fumagalli, Federico Moro, Lucia Caffino, +7

The International Journal of Neuropsychopharmacology

NeuropsychologySubstance UseBehavioral AddictionPsychopharmacologySocial Sciences +19

Divergent Prelimbic Cortical Pathways Interact with BDNF to Regulate Cocaine-seeking

Giuseppe Giannotti, Sarah M. Barry, Benjamin M. Siemsen, +2

Journal of Neuroscience

Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex

Michel M. M. Verheij, Leandro F. Vendruscolo, Lucia Caffino, +7

Journal of Neuroscience

The Cathinones MDPV and α-PVP Elicit Different Behavioral and Molecular Effects Following Acute Exposure

Giuseppe Giannotti, Isabella Canazza, Lucia Caffino, +4

Neurotoxicity Research

Molecular PharmacologyMolecular EffectsAcute ExposureBehavioral PharmacologyPhysiology +9

Biphasic effect of abstinence duration following cocaine self-administration on spine morphology and plasticity-related proteins in prelimbic cortical neurons projecting to the nucleus accumbens core

Benjamin M. Siemsen, Giuseppe Giannotti, JA McFaddin, +2

Brain Structure and Function

Spine MorphologySubstance AbuseBehavioral NeuroscienceNeuroanatomyAddiction +10

Stress rapidly dysregulates the glutamatergic synapse in the prefrontal cortex of cocaine-withdrawn adolescent rats

Lucia Caffino, Francesca Calabrese, Giuseppe Giannotti, +4

Addiction Biology

Short-term withdrawal from developmental exposure to cocaine activates the glucocorticoid receptor and alters spine dynamics

Lucia Caffino, Giuseppe Giannotti, Chiara Malpighi, +2

European Neuropsychopharmacology

Substance AbusePsychoactive DrugSubstance UseDevelopmental ExposureAddiction +12

Prefrontal cortex neuronal ensembles encoding fear drive fear expression during long-term memory retrieval

Giuseppe Giannotti, Jasper A. Heinsbroek, Alexander J. Yue, +2

Scientific Reports

Extinction blunts paraventricular thalamic contributions to heroin relapse

Giuseppe Giannotti, Sheng Gong, Nicholas Fayette, +5

Cell Reports

Heroin RelapseBehavioral AddictionPsychopharmacologySocial SciencesPvt Inputs +15