Andrew N. Bigley

Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents

Ping-Chuan Tsai, Nicholas G. Fox, Andrew N. Bigley et al. · Biochemistry · 2012 · 123 citations · Full text

Combinatorial Chemistry, Nerve Agent Analogues, Chemical Biology +17

Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis

Andrew N. Bigley, Chengfu Xu, Terry J. Henderson et al. · Journal of the American Chemical Society · 2013 · 122 citations · Full text

Engineering, Molecular Biology, Chemical Warfare Agent +19

Stereoselective Hydrolysis of Organophosphate Nerve Agents by the Bacterial Phosphotriesterase

Ping-Chuan Tsai, Andrew N. Bigley, Yingchun Li et al. · Biochemistry · 2010 · 114 citations

Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents

Peng Zhang, Erik J. Liu, Caroline Tsao et al. · Science Translational Medicine · 2019 · 73 citations

Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR

Andrew N. Bigley, Mark Mabanglo, Steven P. Harvey et al. · Biochemistry · 2015 · 67 citations