Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity

Christian Büll, Thomas J. Boltje, Natasja Balneger, +9

Cancer Research

NANS-mediated synthesis of sialic acid is required for brain and skeletal development

Clara van Karnebeek, Luisa Bonafé, Xiao‐Yan Wen, +43

Nature Genetics

Developmental BiologyBiochemistryBrain DevelopmentSialic AcidNans-mediated Synthesis +5

Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids

Torben Heise, Johan F. A. Pijnenborg, Christian Büll, +6

Journal of Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryChemoprevention StrategySialic Acid BiosynthesisGlycobiology +15

Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation

Christian Büll, Estel Collado Camps, Esther D. Kers‐Rebel, +6

Immunology and Cell Biology

Steering Siglec–Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry

Christian Büll, Torben Heise, Niek van Hilten, +8

Angewandte Chemie International Edition

Sialic Acid Glycoengineering Using an Unnatural Sialic Acid for the Detection of Sialoglycan Biosynthesis Defects and On-Cell Synthesis of Siglec Ligands

Christian Büll, Torben Heise, Daniëlle M. H. Beurskens, +8

ACS Chemical Biology

EngineeringSialic Acid BiosynthesisGlycobiologyChemical BiologyPropargyloxycarbonyl Sialic Acid +15

Selective Inhibition of Sialic Acid-Based Molecular Mimicry in Haemophilus influenzae Abrogates Serum Resistance

Torben Heise, Jeroen D. Langereis, Emiel Rossing, +4

Cell chemical biology

Selective InhibitionAntimicrobial Resistance GeneHealth SciencesPathogenesisMicrobiology +6

Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal  -dystroglycan O-mannosylation, independent from sialic acid

Moniek Riemersma, Julia Sandrock, Thomas J. Boltje, +6

Human Molecular Genetics

GlycobiologyMolecular BiologyPathologyCarbohydrate-protein InteractionAbnormal -Dystroglycan O-mannosylation +17

Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2

Renske J.E. van den Bijgaart, Michiel Kroesen, Melissa Wassink, +11

Journal of Biological Chemistry

Dynamic tracing of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs

Monique van Scherpenzeel, Federica Conte, Christian Büll, +17

Glycobiology

GlycobiologyMetabolomic ProfilingMolecular BiologyPolysaccharideEnzymatic Modification +20