Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2

Tetsuya Taniguchi, Koichi Omura, Keisuke Motoki, +5

Scientific Reports

Metabolic Profile of FYX-051 (4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile) in the Rat, Dog, Monkey, and Human: Identification of N-Glucuronides and N-Glucosides

Takashi Nakazawa, Kengo Miyata, Koichi Omura, +2

Drug Metabolism and Disposition

Ideal pharmacokinetic profile of dotinurad as a selective urate reabsorption inhibitor

Koichi Omura, Kengo Miyata, Seiichi Kobashi, +6

Drug Metabolism and Pharmacokinetics

Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers

Keisuke Motoki, Takako Igarashi, Koichi Omura, +4

Pharmacology Research & Perspectives

Characterization of N-Glucuronidation of 4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): A New Xanthine Oxidoreductase Inhibitor

Koichi Omura, Takashi Nakazawa, Takahiro Sato, +2

Drug Metabolism and Disposition

Identification of Human UDP-Glucuronosyltransferase and Sulfotransferase as Responsible for the Metabolism of Dotinurad, a Novel Selective Urate Reabsorption Inhibitor

Koichi Omura, Keisuke Motoki, Seiichi Kobashi, +3

Drug Metabolism and Disposition