Saraswathi Ponnam

Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle

Saraswathi Ponnam, Ivanka Sevrieva, Yin‐Biao Sun et al. · Proceedings of the National Academy of Sciences · 2019 · 82 citations · Full text

Myosin-containing Thick Filaments, Cardiac Muscle, Engineering +22

Microscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein C

Saraswathi Ponnam, Thomas Kampourakis · Journal of Biological Chemistry · 2021 · 46 citations · Full text

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I

Ivanka Sevrieva, Birgit Brandmeier, Saraswathi Ponnam et al. · Journal of Biological Chemistry · 2020 · 33 citations · Full text

Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle

Thomas Kampourakis, Saraswathi Ponnam, Malcolm Irving · Journal of Molecular and Cellular Cardiology · 2018 · 29 citations · Full text

Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions

Thomas Kampourakis, Saraswathi Ponnam, Yin‐Biao Sun et al. · Journal of Biological Chemistry · 2018 · 24 citations · Full text

Heart Muscle, Cardiac Muscle, Myosin-binding Protein-c Phosphorylation +11