HIV-1 Buds Predominantly at the Plasma Membrane of Primary Human Macrophages

Sonja Welsch, Oliver T. Keppler, Anja Habermann, +3

PLoS Pathogens

Primary MacrophagesImmunologyViral Structural ProteinInflammationHiv-1 Buds Predominantly +15

HIV-1 Antagonism of CD317 Is Species Specific and Involves Vpu-Mediated Proteasomal Degradation of the Restriction Factor

Christine Goffinet, Ina Allespach, Stefanie Homann, +12

Cell Host & Microbe

Restriction FactorHuman RetrovirusImmunologyHiv-1 AntagonismAntiviral Response +10

The Nef Protein of Human Immunodeficiency Virus Establishes Superinfection Immunity by a Dual Strategy to Downregulate Cell-Surface CCR5 and CD4

Nico Michel, Ina Allespach, Stephanie Venzke, +2

Current Biology

Dual StrategyHuman RetrovirusImmunologyAntiviral ResponseVirology +9

Expression of Nef Downregulates CXCR4, the Major Coreceptor of Human Immunodeficiency Virus, from the Surfaces of Target Cells and Thereby Enhances Resistance to Superinfection

Stephanie Venzke, Nico Michel, Ina Allespach, +2

Journal of Virology

ImmunologyMolecular BiologyViral Structural ProteinHuman Immunodeficiency VirusImmunotherapy +16

HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcription

Christine Goffinet, Ina Allespach, Oliver T. Keppler

Proceedings of the National Academy of Sciences

Hiv-susceptible Transgenic RatsVirus EntryHiv-1 Receptor ComplexImmunologyHiv-1 Challenge +16

Rodent Cells Support Key Functions of the Human Immunodeficiency Virus Type 1 Pathogenicity Factor Nef

Oliver T. Keppler, Ina Allespach, Lismarie Schüller, +3

Journal of Virology

ImmunologyHuman Immunodeficiency VirusImmunotherapyHuman RetrovirusImmunopathology +16

Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression

Christine Goffinet, Nico Michel, Ina Allespach, +5

Retrovirology

Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo

Nico Michel, Christine Goffinet, Kerstin Ganter, +7

Retrovirology

Pharmacovirological Impact of an Integrase Inhibitor on Human Immunodeficiency Virus Type 1 cDNA Species In Vivo

Christine Goffinet, Ina Allespach, Lena Oberbremer, +8

Journal of Virology

ImmunologyPathologyAntiviral DrugImmunotherapyHuman Retrovirus +14

Biological Signature Characteristics of Primary Isolates from Human Immunodeficiency Virus Type 1 Group O in Ex Vivo Human Tonsil Histocultures

Silvia Geuenich, Lars Kaderali, Ina Allespach, +2

Journal of Virology

Group M VirusesImmunologyViral DynamicGroup MHuman Retrovirus +16