Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

Lei Lv, Li Dong, Di Zhao, +11

Molecular Cell

Cell AutophagyMitophagyBiochemistryM2 IsoformAutophagy +9

Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase

Yunhang Guo, Ye Liu, Nan Hu, +30

Journal of Medicinal Chemistry

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

Lei Lv, Yan-Ping Xu, Di Zhao, +9

Molecular Cell

Signal TransductionSignaling PathwayCell RegulationNatural SciencesReceptor Tyrosine Kinase +10

WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress Leukemia Cell Proliferation

Yiping Wang, Mengtao Xiao, Xiufei Chen, +12

Molecular Cell

Cell RegulationMedicineWt1 Recruits Tet2Gene ExpressionCancer Cell Biology +8

Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy

Yanping Xu, Lei Lv, Ying Liu, +8

Journal of Clinical Investigation

Pd-l1 GenesImmunologyImmune RegulationImmunoeditingImmunotherapeutics +14

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1

Ruonan Zhang, Yajing Yang, Wenjing Dong, +10

Proceedings of the National Academy of Sciences

Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase

Yanping Xu, Fulong Li, Lei Lv, +6

Cancer Research

Metabolic RemodelingRedox BiologyOxidative StressNadph HomeostasisProteomics +16

Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats

Guangyan Yan, Yina Huang, Qian Bu, +8

Journal of Environmental Science and Health Part A

Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway

Yan Li, Zhengtao Hu, Bo Chen, +13

Toxicology Letters

Cell AutophagyMitophagyPc12 CellsMedicineAutophagy +6

CRL4VprBP E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases

Tadashi Nakagawa, Lei Lv, Makiko Nakagawa, +7

Molecular Cell

Chromatin BindingChromatinTranscriptional RegulationChromatin StructureChromatin Remodeling +10