Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

Bo Zhou, Jia-yuan Zhang, Xian-shuo Liu, +7

Cell Research

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

Jia-yuan Zhang, Bo Zhou, Ru-yue Sun, +10

Cell Research

Cytosporone B is an agonist for nuclear orphan receptor Nur77

Yan-yan Zhan, Xiping Du, Hang‐zi Chen, +20

Nature Chemical Biology

Signal TransductionSignaling PathwayMolecular RegulationNatural SciencesCytosporone B +8

Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment

Peipei Hou, Lijuan Luo, Hang‐zi Chen, +12

Molecular Cell

Tumor BiologyCell RegulationMedicineImmunologyAutophagy +8

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

Weijia Wang, Yuan Wang, Hang‐zi Chen, +23

Nature Chemical Biology

Cell AutophagyMitophagySignal TransductionMitochondrial FunctionApoptosis +7

The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK

Yan-yan Zhan, Yan Chen, Qian Zhang, +22

Nature Chemical Biology

Molecular PhysiologySignal TransductionSignaling PathwayCell RegulationMolecular Regulation +6

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

Li Li, Yuan Liu, Hang‐zi Chen, +14

Nature Chemical Biology

InflammationCytokineAnti-inflammatoryMedicineAutophagy +6

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation

Xiao-Xue Li, Zhijing Wang, Yu Zheng, +10

Molecular Cell

BiochemistryMelanomaMetabolic RegulationMetabolic StressFatty Acid Oxidation +7

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Xueli Bian, Hang‐zi Chen, Pengbo Yang, +12

Nature Communications

Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression

Pengbo Yang, Peipei Hou, Fuyuan Liu, +16

Proceedings of the National Academy of Sciences