A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Chloé James, Valérie Ugo, Jean‐Pierre Le Couedic, +11

Nature

Hematological MalignancySignal TransductionReceptor Tyrosine KinaseMalignant Blood DisorderHematology +7

JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis

Catherine Lacout, Didier F. Pisani, M Tulliez, +3

Blood

A role for reactive oxygen species in JAK2V617F myeloproliferative neoplasm progression

Caroline Marty, Catherine Lacout, Nathalie Droin, +6

Leukemia

Hematological MalignancyTumor BiologyMedicineHematologyPathology +6

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice

Caroline Marty, Catherine Lacout, Antoine Martin, +5

Blood

An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor

Judith Staerk, Catherine Lacout, Takeshi Sato, +3

Blood

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα

Salma Hasan, Catherine Lacout, Caroline Marty, +4

Blood

Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells

Loïc Garçon, Christine Rivat, Chloé James, +6

Blood

BCR–ABL activates STAT3 via JAK and MEK pathways in human cells

Paul Coppo, Stéphane Flamant, Véronique Mansat‐De Mas, +7

British Journal of Haematology

Molecular RegulationMixed-phenotype Acute LeukemiaImmunologyTumor BiologyMyeloid Neoplasia +18

The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation

Claude Capron, Yann Lécluse, Anna Lila Kaushik, +12

Blood

A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome

Catherine Lacout, Élie Haddad, Siham Sabri, +9

Blood