Hirotaka Kimata

Discovery of Canagliflozin, a Novel <i>C</i>-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

Sumihiro Nomura, Shigeki Sakamaki, Mitsuya Hongu et al. · Journal of Medicinal Chemistry · 2010 · 379 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Mineralocorticoid Receptor Antagonism Attenuates Cardiac Hypertrophy and Failure in Low-Aldosterone Hypertensive Rats

Kohzo Nagata, Koji Obata, Jinglan Xu et al. · Hypertension · 2006 · 223 citations

Medicine, Cardiology, Pharmacology +15

Pitavastatin Improves Cardiac Function and Survival in Association With Suppression of the Myocardial Endothelin System in a Rat Model of Hypertensive Heart Failure

Masako Saka, Koji Obata, Sahoko Ichihara et al. · Journal of Cardiovascular Pharmacology · 2006 · 52 citations

Medicine, Cardiology, Pharmacology +17

Analysis of the Effect of Canagliflozin on Renal Glucose Reabsorption and Progression of Hyperglycemia in Zucker Diabetic Fatty Rats

Chiaki Kuriyama, Jun Xu, Seunghun Paul Lee et al. · Journal of Pharmacology and Experimental Therapeutics · 2014 · 52 citations

Pharmacy, Pharmacology, Pharmacotherapy +17

Novel Indole-<i>N</i>-glucoside, TA-1887 As a Sodium Glucose Cotransporter 2 Inhibitor for Treatment of Type 2 Diabetes

Sumihiro Nomura, Yasuo Yamamoto, Yosuke Matsumura et al. · ACS Medicinal Chemistry Letters · 2013 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15