Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

Jeremiah D. Osteen, Volker Herzig, John M. Gilchrist, +17

Nature

MechanobiologyNav1.1 ChannelHealth SciencesPain MedicineMedicine +10

The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel

Christian J. Peters, John M. Gilchrist, Jason Tien, +7

Neuron

Molecular PhysiologySignal TransductionBiochemistryNatural SciencesMembrane Transport +11

Crystallographic insights into sodium-channel modulation by the β4 subunit

John M. Gilchrist, Samir Das, Filip Van Petegem, +1

Proceedings of the National Academy of Sciences

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

Niraj S. Bende, Sławomir Dziemborowicz, Mehdi Mobli, +6

Nature Communications

BiologyToxinologyPesticide ResistancePhysiologyEntomology +7

TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis

David Crottès, Yu-Hsiu T. Lin, Christian J. Peters, +4

Proceedings of the National Academy of Sciences

Na_v1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents

John M. Gilchrist, Stacey B. B. Dutton, Marcelo Diaz-Bustamante, +5

ACS Chemical Biology

Molecular PharmacologyMedicinal ChemistryNeurophysiologySodium HomeostasisUnique Rufinamide Scaffold +13

NaV1.1 inhibition can reduce visceral hypersensitivity

Juan Salvatierra, Joel Castro, Andelain Erickson, +13

JCI Insight

Pain MedicineImmunologyMolecular PainNav1.1 InhibitionIrritable Bowel Syndrome +15

Binary architecture of the Nav1.2-β2 signaling complex

Samir Das, John M. Gilchrist, Frank Bosmans, +1

eLife

Crystal StructureSignal TransductionMolecular PhysiologyBiochemistryBiomolecular Structure Prediction +12

Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action

John M. Gilchrist, Nien-Du Yang, Victoria Jiang, +1

Molecular Pharmacology

Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami

Volker Herzig, Maria P. Ikonomopoulou, Jennifer J. Smith, +8

Scientific Reports