Hepatocyte Nuclear Factor-4α Is Essential for Glucose-stimulated Insulin Secretion by Pancreatic β-Cells

Atsuko Miura, Kazuya Yamagata, Masafumi Kakei, +12

Journal of Biological Chemistry

The HNF-1 target Collectrin controls insulin exocytosis by SNARE complex formation

Kenji Fukui, Qin Yang, Yang Cao, +18

Cell Metabolism

Snare Complex FormationInsulin SignalingSignal TransductionBiochemistryHnf-1 Target Collectrin +11

Sequential exocytosis of insulin granules is associated with redistribution of SNAP25

Noriko Takahashi, Hiroyasu Hatakeyama, Haruo Okado, +5

The Journal of Cell Biology

Palmitate-induced Down-regulation of Sortilin and Impaired GLUT4 Trafficking in C2C12 Myotubes

Yo Tsuchiya, Hiroyasu Hatakeyama, Natsumi Emoto, +3

Journal of Biological Chemistry

Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets

Hiroyasu Hatakeyama, Takuya Kishimoto, Tomomi Nemoto, +2

The Journal of Physiology

OptogeneticsCellular PhysiologyInsulin SignalingMouse Pancreatic IsletsProtein Kinase A +16

SNARE Conformational Changes that Prepare Vesicles for Exocytosis

Noriko Takahashi, Hiroyasu Hatakeyama, Haruo Okado, +3

Cell Metabolism

ExosomesMedicineNatural SciencesExtracellular MicrovesiclesMembrane Biology +7

Two cAMP‐dependent pathways differentially regulate exocytosis of large dense‐core and small vesicles in mouse β‐cells

Hiroyasu Hatakeyama, Noriko Takahashi, Takuya Kishimoto, +2

The Journal of Physiology

Camp‐dependent PathwaysProtein SecretionExtracellular MicrovesiclesCytoskeletonOptogenetics +22

Identification of Three Distinct Functional Sites of Insulin-mediated GLUT4 Trafficking in Adipocytes Using Quantitative Single Molecule Imaging

Hideaki Fujita, Hiroyasu Hatakeyama, Tomonobu M. Watanabe, +3

Molecular Biology of the Cell

Quantum Dot TechnologyCytoskeletonInsulin SignalingGlucose UptakeCellular Physiology +17

Characterization of contraction-inducible CXC chemokines and their roles in C₂C₁₂myocytes

Taku Nedachi, Hiroyasu Hatakeyama, Tatsuyoshi Kono, +2

American Journal of Physiology-Endocrinology and Metabolism

Skeletal Muscle CellsMuscle FunctionChemokine BiologyImmunologyImmunologic Mechanism +22

Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion

Yuichiro Munakata, Tetsuya Yamada, Junta Imai, +15

Scientific Reports