SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response

Yongzhen Liu, Chao Qin, Youliang Rao, +16

mBio

Teleost-Specific TLR19 Localizes to Endosome, Recognizes dsRNA, Recruits TRIF, Triggers both IFN and NF-κB Pathways, and Protects Cells from Grass Carp Reovirus Infection

Jianfei Ji, Youliang Rao, Quanyuan Wan, +2

The Journal of Immunology

The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness

Kyumin Kim, Peter Calabrese, Shanshan Wang, +4

Scientific Reports

Viral ReplicationEngineeringGeneticsImmunologyMolecular Biology +16

ROS-induced HSP70 promotes cytoplasmic translocation of high-mobility group box 1b and stimulates antiviral autophagy in grass carp kidney cells

Youliang Rao, Quanyuan Wan, Hang Su, +6

Journal of Biological Chemistry

Trunk kidney of grass carp (Ctenopharyngodon idella) mediates immune responses against GCRV and viral/bacterial PAMPs in vivo and in vitro

Lijun Chen, Qingmei Li, Jianguo Su, +3

Fish & Shellfish Immunology

Host ResponseGrass CarpPathogenesisViral PathogenesisImmunology +11

MDA5 Induces a Stronger Interferon Response than RIG-I to GCRV Infection through a Mechanism Involving the Phosphorylation and Dimerization of IRF3 and IRF7 in CIK Cells

Quanyuan Wan, Chunrong Yang, Youliang Rao, +2

Frontiers in Immunology

Molecular characterizations of grass carp (Ctenopharyngodon idella) TBK1 gene and its roles in regulating IFN-I pathway

Xiaoli Feng, Jianguo Su, Chunrong Yang, +2

Developmental & Comparative Immunology

BiologyMolecular RegulationGrass CarpGeneticsNatural Sciences +9

Viperin catalyzes methionine oxidation to promote protein expression and function of helicases

Lei Bai, Jiazhen Dong, Zhenqiu Liu, +3

Science Advances

Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis

Jun Zhao, Mao Tian, Shu Zhang, +14

Cell Metabolism

InflammationDeamidation ShuntsSepsisMetabolic RemodelingReperfusion Injury +1

Grass Carp Laboratory of Genetics and Physiology 2 Serves As a Negative Regulator in Retinoic Acid-Inducible Gene I- and Melanoma Differentiation-Associated Gene 5-Mediated Antiviral Signaling in Resting State and Early Stage of Grass Carp Reovirus Infection

Youliang Rao, Quanyuan Wan, Chunrong Yang, +1

Frontiers in Immunology