Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors

Keshav Karki, Erik Hedrick, Ravi Kasiappan, +2

Cancer Prevention Research

Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer

Ravi Kasiappan, Indira Jutooru, Keshav Karki, +2

Journal of Biological Chemistry

Chemoprevention StrategyBenzyl IsothiocyanateImmunologyCell DeathSpecificity Proteins +16

Dopamine is an aryl hydrocarbon receptor agonist

Hyejin Park, Un-Ho Jin, Keshav Karki, +5

Biochemical Journal

Molecular PharmacologyBiochemistryFunctional SelectivityNeuroactive Hormone DopamineMedicine +13

A Bis-Indole–Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity

Keshav Karki, Gus A. Wright, Kumaravel Mohankumar, +3

Cancer Research

The aryl hydrocarbon receptor is a tumor suppressor–like gene in glioblastoma

Un-Ho Jin, Keshav Karki, Yating Cheng, +3

Journal of Biological Chemistry

Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas

Keshav Karki, Xi Li, Un-Ho Jin, +6

Journal of Neuro-Oncology

Molecular PharmacologyNeuro-oncologyDrug TargetingGliomaG Protein-coupled Receptor +7

Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors

Ravi Kasiappan, Indira Jutooru, Kumaravel Mohankumar, +3

Molecular Cancer Research

NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth

Keshav Karki, Kumaravel Mohankumar, Abigail Schoeller, +3

Cancers

Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer

Kumaravel Mohankumar, Xi Li, Subhashree Sridharan, +2

Gynecologic Oncology

Ros-dependent InhibitionSignaling PathwayMedicineHormonal ReceptorGynecology +8

Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK

Un-Ho Jin, Keshav Karki, Sang-Bae Kim, +1

Biochemical and Biophysical Research Communications

Pancreatic CancerChemoprevention StrategyBiochemistryMedicinePharmacology +2