Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Eri Kobayashi, Takafumi Suzuki, Ryo Funayama, +8

Nature Communications

Inflammatory Lung DiseaseLung InflammationRedox ControlImmunologyImmune Regulation +18

GlcNAcylation of histone H2B facilitates its monoubiquitination

Ryoji Fujiki, Waka Hashiba, Hiroki Sekine, +13

Nature

Histone ModificationsChromatinChromatin RemodelingEpigenetic ChangeEpigenomics +4

Hypersensitivity of Aryl Hydrocarbon Receptor-Deficient Mice to Lipopolysaccharide-Induced Septic Shock

Hiroki Sekine, Junsei Mimura, Motohiko Oshima, +7

Molecular and Cellular Biology

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling

Tomokazu Souma, Masahiro Nezu, Daisuke Nakano, +11

Journal of the American Society of Nephrology

Renal Epo-producing CellsImmunologyRenal InflammationCellular PhysiologyRedox Biology +18

White matter changes caused by chronic solvent abuse.

Naoto Yamanouchi, Shinichiro Okada, Kazuhiro Kodama, +6

PubMed

Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2

Md. Morshedul Alam, Keito Okazaki, Linh Thi Thao Nguyen, +7

Journal of Biological Chemistry

Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis.

Tsutomu Takeuchi, Koichi Amano, Hiroki Sekine, +2

Journal of Clinical Investigation

InflammationRheumatologyIntegrin Adhesive ReceptorsAutoimmune DiseaseAllergy +12

The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression

Hiroki Sekine, Keito Okazaki, Nao Ota, +7

Molecular and Cellular Biology

Antioxidant GenesMediator SubunitsMolecular BiologyRedox BiologyOxidative Stress +15

Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers

Keito Okazaki, Hayato Anzawa, Zun Liu, +18

Nature Communications

Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes

Masahiro Nezu, Tomokazu Souma, Lei Yu, +11

Science Signaling

Lipid PeroxidationCell DeathFetal OutcomesPreeclampsia Mouse ModelEmbryology +21