Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Jianxin Fu, Bo Wei, Tao Wen, +14

Journal of Clinical Investigation

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function

David R. Raleigh, Devin M. Boe, Dan Yu, +8

The Journal of Cell Biology

Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease

Emily Bradford, Hyunji Ryu, Ajay P. Singh, +14

The Journal of Immunology

Placental Syncytium Forms a Biophysical Barrier against Pathogen Invasion

Varvara B. Zeldovich, Casper Hyttel Clausen, Emily Bradford, +4

PLoS Pathogens

Redistribution of the tight junction protein ZO-1 during physiological shedding of mouse intestinal epithelial cells

Yanfang Guan, Alastair J.M. Watson, Amanda M. Marchiando, +4

American Journal of Physiology-Cell Physiology

CytoskeletonDigestive TractCellular PhysiologyTight JunctionCell Interaction +15

The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer

Yang-An Wen, Xiaopeng Xiong, Timothy Scott, +9

Cell Death and Differentiation

MedicineRegulates WntColorectal CancerPathologyCancer Biology +6

Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice

Lane L. Clarke, Lara R. Gawenis, Emily Bradford, +8

American Journal of Physiology-Gastrointestinal and Liver Physiology

DysbiosisMicrobial PathogensBacterial ColonizationPaneth CellsPathogenesis +9

Reduced NHE3-mediated Na⁺ absorption increases survival and decreases the incidence of intestinal obstructions in cystic fibrosis mice

Emily Bradford, Maureen A. Sartor, Lara R. Gawenis, +2

American Journal of Physiology-Gastrointestinal and Liver Physiology

InflammationGlutathione MetabolismIntestinal ContentsMolecular PhysiologySodium Homeostasis +13

AE2 Cl⁻/HCO₃⁻exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon

Lara R. Gawenis, Emily Bradford, Seth L. Alper, +2

American Journal of Physiology-Gastrointestinal and Liver Physiology

Protein SecretionGastrointestinal PharmacologyGastroenterologyCellular PhysiologyMolecular Pharmacology +20

Beta-catenin cleavage enhances transcriptional activation

Tatiana Goretsky, Emily Bradford, Qing Ye, +10

Scientific Reports