Hongrui Lei

Discovery of Novel Indole-Based Allosteric Highly Potent ATX Inhibitors with Great <i>In Vivo</i> Efficacy in a Mouse Lung Fibrosis Model

Hongrui Lei, Ming Guo, Xiaopeng Li et al. · Journal of Medicinal Chemistry · 2020 · 35 citations · Full text

Precise engineering of disulfide bond-bridged prodrug nanoassemblies to balance antitumor efficacy and safety

Yixin Sun, Simeng Wang, Yaqi Li et al. · Acta Biomaterialia · 2022 · 32 citations

Nanomedicine, Precise Engineering, Engineering +8

Design, synthesis and biological evaluation of novel 4-arylaminopyrimidine derivatives possessing a hydrazone moiety as dual inhibitors of L1196M ALK and ROS1

Yu Wang, Guogang Zhang, Gang Hu et al. · European Journal of Medicinal Chemistry · 2016 · 30 citations · Full text

Medicinal Chemistry, Novel 4-Arylaminopyrimidine Derivatives, Biochemistry +8

Discovery and optimization of tetrahydropyrido[4,3-d]pyrimidine derivatives as novel ATX and EGFR dual inhibitors

Tongfei Jing, Xiuqi Miao, Feng Jiang et al. · Bioorganic & Medicinal Chemistry · 2018 · 26 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +8

Discovery of novel mutant-combating ALK and ROS1 dual inhibitors bearing imidazolidin-2-one moiety with reasonable PK properties

Hongrui Lei, Nan Jiang, Xiuqi Miao et al. · European Journal of Medicinal Chemistry · 2019 · 19 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Drug Target +11