Sex‐specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling

Francesca Melancia, Sara Schiavi, Michela Servadio, +5

British Journal of Pharmacology

Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid

Michela Servadio, Francesca Melancia, Antonia Manduca, +7

Translational Psychiatry

Autism Spectrum DisordersSocial SciencesPsychologyNeurodiversityAnandamide Activity +16

Sex‐specific behavioural deficits induced at early life by prenatal exposure to the cannabinoid receptor agonist WIN55, 212‐2 depend on mGlu5 receptor signalling

Antonia Manduca, Michela Servadio, Francesca Melancia, +3

British Journal of Pharmacology

Reward-Related Behavioral, Neurochemical and Electrophysiological Changes in a Rat Model of Autism Based on Prenatal Exposure to Valproic Acid

Sara Schiavi, Daniela Iezzi, Antonia Manduca, +7

Frontiers in Cellular Neuroscience

NeuropsychologyVpa-exposed RatsRat ModelSocial SciencesPsychology +18

Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid

Michela Servadio, Antonia Manduca, Francesca Melancia, +7

European Neuropsychopharmacology

Dna DamageDevelopmental BiologyBrain DevelopmentAutistic-like TraitsGenetics +7

Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome

Thomas Maurin, Francesca Melancia, Marielle Jarjat, +18

Cerebral Cortex

Molecular BiologyPde2a Enzymatic ActivityNewborn Fmr1-ko MiceExperimental NeuropathologyNeurology +19

Lipid nanoparticles for administration of poorly water soluble neuroactive drugs

Elisabetta Esposito, Markus Drechsler, Paolo Mariani, +8

Biomedical Microdevices

NanoparticlesEngineeringLipid NanoparticlesNano-drug DeliveryBiomedical Engineering +2

Testing the correlation between experimentally-induced hypothyroidism during pregnancy and autistic-like symptoms in the rat offspring

Francesca Melancia, Michela Servadio, Sara Schiavi, +3

Behavioural Brain Research

Experimentally-induced HypothyroidismNeuroendocrine DisorderAutismThyroid DisordersNeuroscience +4

Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder

Sara Schiavi, Emilia Carbone, Francesca Melancia, +7

Translational Psychiatry