Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors

Chatchai Muanprasat, N.D. Sonawane, Danieli B. Salinas, +3

The Journal of General Physiology

Nanomolar Affinity Small Molecule Correctors of Defective ΔF508-CFTR Chloride Channel Gating

Hong Yang, Anang A. Shelat, R. Kiplin Guy, +9

Journal of Biological Chemistry

Phenylglycine and Sulfonamide Correctors of Defective ΔF508 and G551D Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Gating

Nicoletta Pedemonte, N.D. Sonawane, Alessandro Taddei, +10

Molecular Pharmacology

Altered channel gating mechanism for CFTR inhibition by a high‐affinity thiazolidinone blocker

Alessandro Taddei, Chiara Folli, Olga Zegarra‐Moran, +3

FEBS Letters

Differential Sensitivity of the Cystic Fibrosis (CF)-associated Mutants G551D and G1349D to Potentiators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl– Channel

Zhiwei Cai, Alessandro Taddei, David N. Sheppard

Journal of Biological Chemistry

Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach

Andrea R. Beccari, Marica Gemei, Matteo Lo Monte, +12

Scientific Reports

Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors

Gilles Ouvry, Laurence Clary, Loïc Tomas, +20

ACS Medicinal Chemistry Letters