Wenxin Du

Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

Liguo Wang, Xuejing Shao, Tianbai Zhong et al. · Nature Chemical Biology · 2021 · 150 citations

Aml Differentiation Therapy, Receptor Tyrosine Kinase, Cell Biology +4

Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells

Xuejing Shao, Yingqian Chen, Wei Wang et al. · Acta Pharmaceutica Sinica B · 2021 · 60 citations · Full text

Palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML

Xuejing Shao, Aixiao Xu, Wenxin Du et al. · Blood · 2023 · 37 citations

Deneddylation of PML/RARα reconstructs functional PML nuclear bodies via orchestrating phase separation to eradicate APL

Xuejing Shao, Yingqian Chen, Aixiao Xu et al. · Cell Death and Differentiation · 2022 · 25 citations · Full text

Molecular Biology, Phase Separation, Medicine +2

Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile

Tingting Jin, Lei Xu, Peipei Wang et al. · Journal of Medicinal Chemistry · 2021 · 16 citations · Full text