An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

Nazish Sayed, Yingxiang Huang, Khiem Nguyen, +23

Nature Aging

InflammationEngineeringAgingDeep LearningLongevity +7

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

Arun Sharma, Paul W. Burridge, Wesley L. McKeithan, +16

Science Translational Medicine

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

Ji‐Eun Lee, Nazish Sayed, Arwen L. Hunter, +6

Cell

GeneticsInnate Immune SystemGenomic MechanismGene RegulationInnate Immunity +4

Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond

Chun Liu, Angelos Oikonomopoulos, Nazish Sayed, +1

Development

NO and CO differentially activate soluble guanylyl cyclase via a heme pivot‐bend mechanism

Xiaolei Ma, Nazish Sayed, Annie Beuve, +1

The EMBO Journal

Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation

Nazish Sayed, Padmamalini Baskaran, Xiaolei Ma, +2

Proceedings of the National Academy of Sciences

Isolated AortaCellular PhysiologyOxidative StressInflammationMolecular Pharmacology +17

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer

Tomoya Kitani, Sang‐Ging Ong, Chi Keung Lam, +10

Circulation

Transdifferentiation of Human Fibroblasts to Endothelial Cells

Nazish Sayed, Wing Tak Wong, Frank Ospino, +6

Circulation

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

Elena Matsa, Paul W. Burridge, Kun-Hsing Yu, +14

Cell stem cell

Translational MedicineCardiomyopathyMedicineTranscriptome ProfilingPatient-specific Human +6

Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells

David T. Paik, Lei Tian, Jaecheol Lee, +11

Circulation Research