David Timms

The Entropic Penalty of Ordered Water Accounts for Weaker Binding of the Antibiotic Novobiocin to a Resistant Mutant of DNA Gyrase:  A Thermodynamic and Crystallographic Study

Geoffrey A. Holdgate, Alan Riboldi‐Tunnicliffe, Walter H.J. Ward et al. · Biochemistry · 1997 · 206 citations

Molecular Biology, Antibiotic Novobiocin, Water Molecules +19

Kinetic and Structural Characteristics of the Inhibition of Enoyl (Acyl Carrier Protein) Reductase by Triclosan

Walter H.J. Ward, Geoffrey A. Holdgate, Siân Rowsell et al. · Biochemistry · 1999 · 159 citations

Structural Characteristics, Acyl Carrier Protein, Biochemistry +15

Construction of protein analogs by site-specific condensation of unprotected fragments

Hubert Gaertner, Keith Rose, Ron Cotton et al. · Bioconjugate Chemistry · 1992 · 143 citations

Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor

Richard A. Norman, Simon T. Barry, Michael Bate et al. · Structure · 2004 · 97 citations · Full text

Crystal Structure, Biochemistry, Natural Sciences +8

Prevention of MKK6-Dependent Activation by Binding to p38α MAP Kinase

Jane E. Sullivan, Geoffrey A. Holdgate, Douglas A. Campbell et al. · Biochemistry · 2005 · 89 citations

Mkk6-dependent Activation, Drug Target, Molecular Regulation +23