Quantification of uric acid, xanthine and hypoxanthine in human serum by HPLC for pharmacodynamic studies

Nancy Cooper, Reza Khosravan, Carol Erdmann, +2

Journal of Chromatography B

MedicineBioanalysisPharmacologyPhysiologyAnalytical Chemistry +10

Pharmacokinetics and Pharmacodynamics of Febuxostat, a New Non-purine Selective Inhibitor of Xanthine Oxidase in Subjects with Renal Impairment

Michael D. Mayer, Reza Khosravan, Laurent Vernillet, +3

American Journal of Therapeutics

Pharmacokinetics, Pharmacodynamics and Safety of Febuxostat, a Non-Purine Selective Inhibitor of Xanthine Oxidase, in a Dose Escalation Study in Healthy Subjects

Reza Khosravan, Brian Grabowski, Jingtao Wu, +2

Clinical Pharmacokinetics

Healthy SubjectsPharmacological StudyPharmacologyXanthine OxidasePharmacotherapy +4

Febuxostat (TMX‐67), a Novel, Non‐Purine, Selective Inhibitor of Xanthine Oxidase, Is Safe and Decreases Serum Urate in Healthy Volunteers

Michael A. Becker, James C. Kisicki, Reza Khosravan, +5

Nucleosides Nucleotides & Nucleic Acids

Molecular PharmacologyAdverse EventsUrologyRenal FunctionUrological Research +13

Randomized phase II study of sunitinib versus standard of care for patients with previously treated advanced triple-negative breast cancer

Giuseppe Curigliano, Xavier Pivot, Javier Cortés, +8

The Breast

Breast OncologyOncologyCancer ManagementPhase Ii StudyBreast Cancer +4

The Effect of Mild and Moderate Hepatic Impairment on Pharmacokinetics, Pharmacodynamics, and Safety of Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase

Reza Khosravan, Brian Grabowski, Michael D. Mayer, +3

The Journal of Clinical Pharmacology

Effect of food or antacid on pharmacokinetics and pharmacodynamics of febuxostat in healthy subjects

Reza Khosravan, Brian Grabowski, Jingtao Wu, +2

British Journal of Clinical Pharmacology

Pharmacokinetics and Safety of Sunitinib Malate in Subjects With Impaired Renal Function

Reza Khosravan, Melvin Toh, May Garrett, +6

The Journal of Clinical Pharmacology

HemodialysisUrologyRenal FunctionSunitinib MalateKidney Research +13

Metabolism and Excretion of [¹⁴C] Febuxostat, a Novel Nonpurine Selective Inhibitor of Xanthine Oxidase, in Healthy Male Subjects

Brian Grabowski, Reza Khosravan, Laurent Vernillet, +1

The Journal of Clinical Pharmacology

Pharmacological StudyBiochemistryMedicineTotal RadioactivityPhysiology +13

Transbuccal permeation of a nucleoside analog, dideoxycytidine: effects of menthol as a permeation enhancer

Amir H. Shojaei, Mansoor A. Khan, Gerald Lim, +1

International Journal of Pharmaceutics

BiochemistryNucleoside AnalogPermeation EnhancerPharmacologyTransbuccal Permeation +1