Brain-specific Phgdh Deletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, an N-methyl-d-aspartate Receptor Co-agonist, in Adult Brain

Jung Hoon Yang, Akira Wada, Kazuyuki Yoshida, +14

Journal of Biological Chemistry

NeurotransmitterBrain-specific Phgdh DeletionNeurochemical BiomarkersSocial SciencesL-serine Biosynthesis +17

Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L

Shoko Tamai, Hiroshi Iida, Sadaki Yokota, +6

Journal of Cell Science

GeneticsMitochondrial VolumeMolecular BiologyMolecular GeneticsMitochondrial Biology +19

An RNAi Screen for Mitochondrial Proteins Required to Maintain the Morphology of the Organelle in Caenorhabditis elegans

Ryohei Ichishita, Kousuke Tanaka, Yoshimi Sugiura, +3

The Journal of Biochemistry

l-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation

Kayoko Esaki, Tomoko Sayano, Chiaki Sonoda, +7

Journal of Biological Chemistry

Identification of a Novel Protein MICS1 that is Involved in Maintenance of Mitochondrial Morphology and Apoptotic Release of Cytochrome c

Toshihiko Oka, Tomoko Sayano, Shoko Tamai, +4

Molecular Biology of the Cell

Novel Protein Mics1Signal TransductionBiochemistryMitochondrial FunctionMedicine +13

Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol

Hisako Akiyama, Mitsuko Ide, Yasuko Nagatsuka, +10

Journal of Biological Chemistry

Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency

Shigeki Furuya, Kazuyuki Yoshida, Yuriko Kawakami, +6

Functional & Integrative Genomics

Signal TransductionCellular Enzymology3-Phosphoglycerate Dehydrogenase GeneGeneticsCatabolism +7

Aglycon diversity of brain sterylglucosides: structure determination of cholesteryl- and sitosterylglucoside

Hisako Akiyama, Kazuki Nakajima, Tomoko Sayano, +4

Journal of Lipid Research

<scp>l</scp>‐Serine deficiency caused by genetic <i><scp>P</scp>hgdh</i> deletion leads to robust induction of 4E‐<scp>BP</scp>1 and subsequent repression of translation initiation in the developing central nervous system

Tomoko Sayano, Yuriko Kawakami, Wataru Kusada, +12

FEBS Journal

Severe Brain MalformationBrain DevelopmentGeneticsMrna TranslationMolecular Genetics +20

Adaptive response to <scp>l</scp>‐serine deficiency is mediated by p38 <scp>MAPK</scp> activation via 1‐deoxysphinganine in normal fibroblasts

Tomoko Sayano, Yuki Kawano, Wataru Kusada, +9

FEBS Open Bio