SARS-CoV-2 viral load is associated with increased disease severity and mortality

Jesse Fajnzylber, James Regan, Kendyll Coxen, +126

Nature Communications

Plasma ViremiaSars-cov-2 Viral LoadViral PersistenceViral DiagnosticsCovid-19 Pandemic +10

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

Naoki Kaneko, Hsiao-Hsuan Kuo, Julie Boucau, +48

Cell

Germinal CentersAdaptive Immune SystemImmunologyHumoral ImmunityCellular Immune Response +4

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

Chenyang Jiang, Xiaodong Lian, Ce Gao, +28

Nature

Viral PersistenceHuman RetrovirusImmunologyAntiviral ResponseViral Dynamic +6

Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy

Kevin Einkauf, Guinevere Q. Lee, Ce Gao, +12

Journal of Clinical Investigation

Viral ReplicationIntact Hiv-1 ProvirusesImmunologyChromatin AccessibilityViral Persistence +15

Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells

Guinevere Q. Lee, Nina Orlova-Fink, Kevin Einkauf, +14

Journal of Clinical Investigation

Genome-intact Hiv-1T-regulatory CellImmunologyT CellsImmunotherapy +15

Phenotypic signatures of immune selection in HIV-1 reservoir cells

Weiwei Sun, Ce Gao, Ciputra Adijaya Hartana, +10

Nature

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

Pilar García‐Broncano, Shivaali Maddali, Kevin Einkauf, +17

Science Translational Medicine

Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy

Xiaodong Lian, Kyra Seiger, Elizabeth M. Parsons, +21

Cell Host & Microbe

Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers

Xiaodong Lian, Ce Gao, Xiaoming Sun, +15

Science Translational Medicine

Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals

Katherine E. Clarridge, Jana Blažková, Kevin Einkauf, +12

PLoS Pathogens

ImmunologyHiv RemissionAntiviral DrugImmune SystemImmunotherapy +14