Lesley A. Pearce

Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero- residue linker a trimer

Alexander A. Kortt, Myoung Soo Lah, Geoffrey W. Oddie et al. · Protein Engineering Design and Selection · 1997 · 132 citations · Full text

Pharmacy, Immunology, Molecular Biology +15

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

Esther Bandala‐Sanchez, Naiara G. Bediaga, Ethan D. Goddard‐Borger et al. · Proceedings of the National Academy of Sciences · 2018 · 89 citations · Full text

Life Sciences, Immunology, Molecular Biology +16

ScFv multimers of the anti-neuraminidase antibody NC10: shortening of the linker in single-chain Fv fragment assembled in VL to VH orientation drives the formation of dimers, trimers, tetramers and higher molecular mass multimers

Olan Dolezal, Lesley A. Pearce, Lynne J. Lawrence et al. · Protein Engineering Design and Selection · 2000 · 87 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Daniel Watterson, Danushka K. Wijesundara, Naphak Modhiran et al. · Clinical & Translational Immunology · 2021 · 61 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

Engineering of an anti‐epidermal growth factor receptor antibody to single chain format and labeling by sortase A‐mediated protein ligation

Mariusz P. Madej, Gregory Coia, Charlotte C. Williams et al. · Biotechnology and Bioengineering · 2011 · 58 citations

Pharmacy, Biotechnology, Molecular Biology +14