Erik J. Hembre

3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-<i>b</i>]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism

Donald R. Gehlert, Andrea Cippitelli, Annika Thorsell et al. · Journal of Neuroscience · 2007 · 242 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Synthesis of Novel Glycosidase-Inhibitory Hydroxymethyl-Substituted Polyhydroxylated Indolizidines:  Ring-Expanded Analogs of the Pyrrolizidine Alkaloids Alexine and Australine

William H. Pearson, Erik J. Hembre · The Journal of Organic Chemistry · 1996 · 72 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Dynamic Kinetic Asymmetric Transformations of Conduritol B Tetracarboxylates:  An Asymmetric Synthesis of <scp>d</scp>-<i>m</i><i>yo</i>-Inositol 1,4,5-Trisphosphate

Barry M. Trost, Daniel E. Patterson, Erik J. Hembre · Journal of the American Chemical Society · 1999 · 64 citations

Natural Sciences, Biochemistry, Chemistry +6

A Practical Synthesis of (−)-Swainsonine

William H. Pearson, Erik J. Hembre · The Journal of Organic Chemistry · 1996 · 64 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1<i>S</i>,3<i>R</i>)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

Junliang Hao, James P. Beck, John M. Schaus et al. · Journal of Medicinal Chemistry · 2019 · 56 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17