Timothy T. Spear

Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide–MHC complexes

Lance M. Hellman, Liusong Yin, Yuan Wang et al. · Journal of Immunological Methods · 2016 · 77 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Atomically accurate de novo design of antibodies with RFdiffusion

Nathaniel R. Bennett, Joseph L. Watson, Robert J. Ragotte et al. · Nature · 2025 · 74 citations · Full text

Pharmacy, Immunology, Molecular Biology +17

How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire

Sydney J. Blevins, Brian G. Pierce, Nishant K. Singh et al. · Proceedings of the National Academy of Sciences · 2016 · 62 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

How an alloreactive T-cell receptor achieves peptide and MHC specificity

Yuan Wang, Nishant K. Singh, Timothy T. Spear et al. · Proceedings of the National Academy of Sciences · 2017 · 58 citations · Full text

Life Sciences, Cell Biology, Immunology +17

TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors

Timothy T. Spear, Glenda G. Callender, J. Roszkowski et al. · Cancer Immunology Immunotherapy · 2016 · 53 citations · Full text

Medicine, Immunology, Oncology +14