The Extremely Conserved C-terminal Region of Reelin Is Not Necessary for Secretion but Is Required for Efficient Activation of Downstream Signaling

Yoshimi Nakano, Takao Kohno, Terumasa Hibi, +5

Journal of Biological Chemistry

Efficient ActivationProtein SecretionReelin MutantsCytoskeletonReelin Is +18

Importance of Reelin C-Terminal Region in the Development and Maintenance of the Postnatal Cerebral Cortex and Its Regulation by Specific Proteolysis

Takao Kohno, Takao Honda, Ken‐ichiro Kubo, +6

Journal of Neuroscience

Cleavage within Reelin Repeat 3 Regulates the Duration and Range of the Signaling Activity of Reelin Protein

Mari Koie, Kyoko Okumura, Arisa Hisanaga, +6

Journal of Biological Chemistry

Reelin ProteinProtein FunctionSignal TransductionDevelopmental BiologyCell Division +8

Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin

Himari Ogino, Arisa Hisanaga, Takao Kohno, +8

Journal of Neuroscience

Mechanism and significance of specific proteolytic cleavage of Reelin

Shiori Kohno, Takao Kohno, Yoshimi Nakano, +5

Biochemical and Biophysical Research Communications

Protein ChemistryProtein FunctionBiochemistryProtein FoldingNatural Sciences +3

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS‐4) cleaves Reelin in an isoform‐dependent manner

Arisa Hisanaga, Shunsuke Morishita, Kenta Suzuki, +4

FEBS Letters

Isoform‐dependent MannerThrombosisAdamts‐4 IsoformsProtein FunctionBiochemistry +12

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

Akira Sobue, Itaru Kushima, Taku Nagai, +12

Scientific Reports

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum

Yuko Yamakage, Michinao Kato, Aya Hongo, +9

Molecular and Cellular Neuroscience

ThrombosisThrombospondin Motifs 2Postnatal Cerebral CortexNeuroanatomyMetalloprotein +8

Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders

Kaori Sakai, Hirotaka Shoji, Takao Kohno, +2

Scientific Reports

Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage

Yoshitaka Sato, Daichi Kobayashi, Takao Kohno, +4

The Journal of Biochemistry

Cleavage SiteProtein AssemblyMolecular BiologyCytoskeletonCellular Neurobiology +22