Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise

J. Robert Newman, Sina Ghaemmaghami, Jan Ihmels, +4

Nature

Proteomic TechnologySingle-cell Proteomic AnalysisFunctional GenomicsSingle Cell SequencingMedicine +12

Orm family proteins mediate sphingolipid homeostasis

David K. Breslow, Sean R. Collins, Bernd Bodenmiller, +5

Nature

Proteinlipid InteractionProtein FunctionOrm FamilyCellular BiochemistryMedicine +2

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome

David K. Breslow, Dale M. Cameron, Sean R. Collins, +7

Nature Methods

Long-read SequencingComprehensive StrategyFunctional GenomicsGeneticsComputational Genomics +11

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in <i>Saccharomyces cerevisiae</i>

Françoise M. Roelants, David K. Breslow, Alexander Muir, +2

Proceedings of the National Academy of Sciences

A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened

Seongjin Seo, Qihong Zhang, Kevin Bugge, +4

PLoS Genetics

Developmental BiologySignal TransductionHedgehog SignalingSignaling PathwayBbsome Subunits +9

The Intraflagellar Transport Protein IFT27 Promotes BBSome Exit from Cilia through the GTPase ARL6/BBS3

Gerald Liew, Fan Ye, Andrew R. Nager, +6

Developmental Cell

Signal TransductionOrganelle DynamicNatural SciencesAutophagySecretory Pathway +12

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, +9

Nature Genetics

Developmental BiologyCrispr-based ScreenCiliary FunctionGene EditingGenome Editing +4

An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier

David K. Breslow, Elena F. Koslover, Federica Seydel, +2

The Journal of Cell Biology

CytoskeletonCellular PhysiologyCell-substrate InteractionsDrug ResistanceMembrane Transport +20

Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

Fan Ye, David K. Breslow, Elena F. Koslover, +3

eLife

Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

Anil Kumar Ganga, Margaret C. Kennedy, Mai E. Oguchi, +7

Current Biology

Ciliary Membrane FormationSignal TransductionDevelopmental BiologySignaling PathwayIntracellular Ciliogenesis Pathway +7