Dirk Maurer

Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

André B. P. Kuilenburg, Judith Meijer, Dirk Maurer et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2016 · 43 citations · Full text

Severe Fluoropyrimidine Toxicity, Drug Resistance, Mrna Splicing +3

Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Dirk Maurer, Thilak Reddy Enugala, Emil Hamnevik et al. · ACS Catalysis · 2018 · 22 citations · Full text

Engineering, Molecular Biology, Organic Chemistry +17

Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a nonpreferred alcohol enantiomer

Emil Hamnevik, Thilak Reddy Enugala, Dirk Maurer et al. · FEBS Journal · 2017 · 21 citations · Full text

Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-diol and Its Corresponding Acyloin

Emil Hamnevik, Dirk Maurer, Thilak Reddy Enugala et al. · Biochemistry · 2018 · 19 citations

Engineering, Molecular Biology, Organic Chemistry +17

Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

Dirk Maurer, Bernhard Lohkamp, Michael Krumpel et al. · Biochemical Journal · 2018 · 13 citations