Karen Leavens

Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor

John Liddle, Francis Atkinson, Michael D. Barker et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 54 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Lymphocyte Activation Gene (LAG)-3 Is Associated With Mucosal Inflammation and Disease Activity in Ulcerative Colitis

Stephanie Slevin, Lucy C. Garner, Conor Lahiff et al. · Journal of Crohn s and Colitis · 2020 · 53 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Depletion of LAG‐3⁺ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781

Joanne Ellis, Daniel JB Marks, Naren Srinivasan et al. · Clinical Pharmacology & Therapeutics · 2020 · 32 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Discovery of <scp>GW</scp>870086: a potent anti‐inflammatory steroid with a unique pharmacological profile

Iain Uings, Dusty A. Parker Needham, J. L. Matthews et al. · British Journal of Pharmacology · 2013 · 27 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

The utility of pharmacokinetic–pharmacodynamic modeling in the discovery and optimization of selective S1P₁agonists

S. Taylor, James R. Gray, Robert Willis et al. · Xenobiotica · 2012 · 10 citations

Pharmacy, Pharmacokinetics, Pharmacology +17