Tomoaki Takakura

PEGylation Confers Greatly Extended Half-Life and Attenuated Immunogenicity to Recombinant Methioninase in Primates

Zhijian Yang, Junhua Wang, Quan Lu et al. · Cancer Research · 2004 · 121 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Endogenous Angiogenesis Inhibitor Vasohibin1 Exhibits Broad-Spectrum Antilymphangiogenic Activity and Suppresses Lymph Node Metastasis

Takahiro Heishi, Tomoko Hosaka, Yasuhiro Suzuki et al. · American Journal Of Pathology · 2010 · 91 citations · Full text

Medicine, Oncology, Pharmacology +12

Chemoenzymatic Synthesis of Glycosylated Glucagon-like Peptide 1: Effect of Glycosylation on Proteolytic Resistance and in Vivo Blood Glucose-Lowering Activity

Taichi Ueda, Kazuyoshi Tomita, Yoshihide Notsu et al. · Journal of the American Chemical Society · 2009 · 74 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Structure of the Antitumour Enzyme L-Methionine  -Lyase from Pseudomonas putida at 1.8 A Resolution

Daizou Kudou, S. Misaki, Miho Yamashita et al. · The Journal of Biochemistry · 2007 · 74 citations

Life Sciences, Biochemistry, Molecular Biology +17

High-level expression and bulk crystallization of recombinant l-methionine γ-lyase, an anticancer agent

Tomoaki Takakura, Takaomi Ito, Shigeo Yagi et al. · Applied Microbiology and Biotechnology · 2005 · 65 citations

Medicine, Cancer Biology, Oncology +9