An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.

Kevin Wang, Rathna Nath, Avigail Posner, +15

Proceedings of the National Academy of Sciences

Inhibitory ActivityMedicinal ChemistryProtein FunctionBiochemistryNatural Sciences +12

Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding

G. Lin, Debasish Chattopadhyay, Masatoshi Maki, +8

Nature Structural Biology

Crystal StructureEnzyme AssemblyProtein AssemblyBiochemistryNatural Sciences +7

Pig heart calpastatin: identification of repetitive domain structures and anomalous behavior in polyacrylamide gel electrophoresis

Emiko Takano, Masatoshi Maki, Hirotaka Mori, +6

Biochemistry

Regulation of Cyclin D1 by Calpain Protease

Yung Hyun Choi, Su‐Jae Lee, Phuongmai Nguyen, +7

Journal of Biological Chemistry

Calpain and calpastatin regulate neutrophil apoptosis

Margaret Squier, Amy J. Sehnert, Karen S. Sellins, +3

Journal of Cellular Physiology

All four internally repetitive domains of pig calpastatin possess inhibitory activities against calpains I and II

Masatoshi Maki, Emiko Takano, Hirotaka Mori, +3

FEBS Letters

Molecular diversity in amino-terminal domains of human calpastatin by exon skipping.

Won Jin Lee, Hong Ma, Emiko Takano, +3

Journal of Biological Chemistry

Analysis of structure-function relationship of pig calpastatin by expression of mutated cDNAs in Escherichia coli.

M. Maki, Emiko Takano, Toshio Osawa, +3

Journal of Biological Chemistry

Molecular PharmacologyInhibitory ActivityCentral RegionMolecular PhysiologySignal Transduction +13

Preference of calcium‐dependent interactions between calmodulin‐like domains of calpain and calpastatin subdomains

Emiko Takano, Hong Ma, Hong Yang, +2

FEBS Letters

Protein AssemblyMolecular BiologyCalmodulin‐like DomainsCalpastatin MoleculeSynthetic Oligopeptides +18

A circular dichroism study of preferential hydration and alcohol effects on a denatured protein, pig calpastatin domain I

Takashi Konno, Naoki Tanaka, Mikio Kataoka, +2

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Protein ChemistryPig Calpastatin DomainBiochemistryProtein FoldingAlcohol Effects +4