Aradhana

High-Throughput Discovery and Characterization of Human Transcriptional Effectors

Josh Tycko, Nicole DelRosso, Gaelen T. Hess et al. · Cell · 2020 · 170 citations · Full text

High-throughput Discovery, Transcriptional Regulation, Functional Genomics +8

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

Josh Tycko, Michael Wainberg, Georgi K. Marinov et al. · Nature Communications · 2019 · 160 citations · Full text

Transcriptomic signatures across human tissues identify functional rare genetic variation

Nicole M. Ferraro, Benjamin J. Strober, Jonah Einson et al. · Science · 2020 · 158 citations · Full text

Large-scale mapping and mutagenesis of human transcriptional effector domains

Nicole DelRosso, Josh Tycko, Peter Suzuki et al. · Nature · 2023 · 125 citations · Full text

Transcriptional Regulation, Large-scale Mapping, Genetics +6

Development of compact transcriptional effectors using high-throughput measurements in diverse contexts

Josh Tycko, Mike V. Van, Aradhana et al. · Nature Biotechnology · 2024 · 33 citations · Full text

Transcriptional Regulation, Functional Genomics, Reporter Gene Assay +13