Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Fadi Rofo, Jos Buijs, Ronny Falk, +8

Translational Neurodegeneration

Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits

Sharn Perry, Martin Larhammar, Jennifer Vieillard, +6

Journal of Neuroscience

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain

Fadi Rofo, Canan Uğur Yılmaz, Nicole G. Metzendorf, +7

Theranostics

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Fadi Rofo, Silvio R. Meier, Nicole G. Metzendorf, +5

Neurotherapeutics

Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Fadi Rofo, Nicole G. Metzendorf, Cristina Saubi, +5

Alzheimer s Research & Therapy

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer’s Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Fadi Rofo, Friederike A. Sandbaumhüter, Aikaterini Chourlia, +6

ACS Chemical Neuroscience

A single‐chain fragment constant design enables easy production of a monovalent blood–brain barrier transporter and provides an improved brain uptake at elevated doses

Jamie I. Morrison, Nicole G. Metzendorf, Fadi Rofo, +2

Journal of Neurochemistry

Standardized Preclinical <i>In Vitro</i> Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways

Jamie I. Morrison, Alex Petrovic, Nicole G. Metzendorf, +4

Molecular Pharmaceutics