Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals

Yichi Su, Joel R. Walker, Yun‐Hee Park, +16

Nature Methods

EngineeringBioluminescenceBiomedical ImagingBiophotonicsBiomedical Engineering +3

Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression

Mariano Carossino, Devin Kenney, Aoife K. O’Connell, +18

Viruses

Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα

Kathryn B. Grandinetti, Tracy A. Stevens, Sang‐Jun Ha, +7

Oncogene

Tumor BiologyHuman Lung CancersMedicineCancer Cell BiologyCancer Biology +7

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Mark E. Gurney, Richard A. Nugent, Xuesheng Mo, +16

Journal of Medicinal Chemistry

Drug TargetEarlier Pde4 InhibitorsLead IdentificationAllosteric InhibitorsChemical Biology +15

An optimized bioluminescent substrate for non-invasive imaging in the brain

Yichi Su, Joel R. Walker, Mary P. Hall, +8

Nature Chemical Biology

NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice—A Novel in Vivo Imaging Platform

Natasa Gaspar, Giorgia Zambito, Iris J. C. Dautzenberg, +9

International Journal of Molecular Sciences

Vivo Imaging PlatformStrong BioluminescenceEngineeringViral DiagnosticsNanobiotechnology +13

Coelenterazine analogues emit red-shifted bioluminescence with NanoLuc

Anton Shakhmin, Mary P. Hall, Thomas Machleidt, +3

Organic & Biomolecular Chemistry

Evaluation of NanoLuc substrates for bioluminescence imaging of transferred cells in mice

Natasa Gaspar, Joel R. Walker, Giorgia Zambito, +4

Journal of Photochemistry and Photobiology B Biology

EngineeringBioluminescence ImagingBiomedical EngineeringTransferred CellsTissue Imaging +16

Highly Potent Cell-Permeable and Impermeable NanoLuc Luciferase Inhibitors

Joel R. Walker, Mary P. Hall, Chad Zimprich, +5

ACS Chemical Biology

Optogenetic Control of Non‐Apoptotic Cell Death

Lian He, Zixian Huang, Kai Huang, +10

Advanced Science

EngineeringApoptosisCell DeathCell Death MechanismsOptogenetics +16