Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

Silvia Svegliati, Giusi Marrone, Antonio Pezone, +11

Science Signaling

Ssc PatientsImmunologyCell DeathPathologySsc Patient Cells +20

DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

Giusi Russo, Rosaria Landi, Antonio Pezone, +7

Scientific Reports

Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene

Alessandra Morano, Tiziana Angrisano, Giandomenico Russo, +12

Nucleic Acids Research

Targeted DNA oxidation by LSD1–SMAD2/3 primes TGF-β1/ EMT genes for activation or repression

Antonio Pezone, Maria Letizia Taddei, Alfonso Tramontano, +14

Nucleic Acids Research

Molecular RegulationMolecular BiologyGrowth Factor β1Cancer BiologyEpigenetics +22

Non-homologous end joining induced alterations in DNA methylation: A source of permanent epigenetic change

Brittany N. Allen, Antonio Pezone, Antonio Porcellini, +2

Oncotarget

Histone ModificationsEpigenetic ChangeGeneticsDna MethylationMolecular Biology +16

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage

Annarita Nappi, Caterina Miro, Antonio Pezone, +15

Nature Communications

Reductive StressSystems BiologyGeneticsThyroid DiseaseTh Concentration +12

Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells

Tiziana Angrisano, Raffaela Pero, Mariarita Brancaccio, +9

PLoS ONE

Histone ModificationsCox-2 GeneEpigenetic ChangeDna MethylationImmunology +17

EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB

Valeria De Pasquale, Antonio Pezone, Patrizia Sarogni, +5

Cell Death and Disease

RNA Stabilizes Transcription-Dependent Chromatin Loops Induced By Nuclear Hormones

Antonio Pezone, Candida Zuchegna, Alfonso Tramontano, +7

Scientific Reports

Morning glory syndrome associated with marked persistent hyperplastic primary vitreous and lens colobomas.

Gilda Cennamo, Giovanna Liguori, Antonio Pezone, +1

British Journal of Ophthalmology

Ocular DiseaseVitreous BodyOphthalmologyOculoplasticsMedicine +8