Rutger Meinsma

Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.

André B. P. Kuilenburg, E.W. Muller, Janet Haasjes et al. · PubMed · 2001 · 255 citations

Dpd Gene, Genetic Disorder, Genetics +13

Increased risk of grade IV neutropenia after administration of 5‐fluorouracil due to a dihydropyrimidine dehydrogenase deficiency: High prevalence of the IVS14+1g>a mutation

André B. P. Kuilenburg, Rutger Meinsma, Lida Zoetekouw et al. · International Journal of Cancer · 2002 · 178 citations · Full text

High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity.

André B. P. Kuilenburg, Rutger Meinsma, Lida Zoetekouw et al. · Pharmacogenetics · 2002 · 172 citations

Genetic Disorder, Medicine, Genetics +13

Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.

André B. P. Kuilenburg, Rutger Meinsma, Bernard A. Zonnenberg et al. · PubMed · 2003 · 138 citations

Genetics, Genetic Epidemiology, Pathology +19

Human Polymorphism in Drug Metabolism: Mutation in the Dihydropyrimidine Dehydrogenase Gene Results in Exon Skipping and Thymine Uracilurea

Rutger Meinsma, Pedro M. Fernández‐Salguero, André B. P. Kuilenburg et al. · DNA and Cell Biology · 1995 · 133 citations

Urology, Family Members, Genetic Disorder +15