Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

Russell M. Lebovitz, Henggui Zhang, Hannes Vogel, +5

Proceedings of the National Academy of Sciences

Cell DeathPerinatal DeathManganese Superoxide DismutaseRedox BiologyMyocardial Injury +15

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

Yi Li, Bryan E. Welm, Katrina Podsypanina, +10

Proceedings of the National Academy of Sciences

Tamoxifen Resistance in Breast Tumors Is Driven by Growth Factor Receptor Signaling with Repression of Classic Estrogen Receptor Genomic Function

Suleiman Massarweh, C. Kent Osborne, Chad J. Creighton, +6

Cancer Research

Insulin-Like Growth Factor-I Activates Gene Transcription Programs Strongly Associated With Poor Breast Cancer Prognosis

Chad J. Creighton, Angelo Casà, ZaWaunyka Lazard, +5

Journal of Clinical Oncology

Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

Thomas Welte, Ik Sun Kim, Lin Tian, +23

Nature Cell Biology

Oncogenic AgentMedicineMyelopoiesisCell BiologyTumor Suppressor +6

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

Xiaoyong Fu, Rinath Jeselsohn, Resel Pereira, +24

Proceedings of the National Academy of Sciences

Breast OncologyCancer BiologyTumor BiologyEr TranscriptomeTranscriptional Regulation +16

The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation Domain

Mark P. de Caestecker, Tetsuro Yahata, David Wang, +6

Journal of Biological Chemistry

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy

Meenu Sharma, Hiep Khong, Faisal Fa’ak, +28

Nature Communications

Generation of an in vitro 3D PDAC stroma rich spheroid model

Matthew J. Ware, Vazrik Keshishian, Justin J. Law, +13

Biomaterials

Tissue EngineeringVitro 3DEngineeringBiofabricationBiomaterial Modeling +8

Development of Resistance to Targeted Therapies Transforms the Clinically Associated Molecular Profile Subtype of Breast Tumor Xenografts

Chad J. Creighton, Suleiman Massarweh, Shixia Huang, +6

Cancer Research

Breast OncologyXenograft ModelsEstrogen ReceptorCancer BiologyTumor Biology +14