Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains

Joshua S. Silverman, Qiang Lü, Alice Bakker, +14

Nature Biotechnology

Protein FunctionSignal TransductionMultivalent Avimer ProteinsG Protein-coupled ReceptorProtein Folding +11

Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

N.S. Laursen, Robert H. Friesen, Xueyong Zhu, +25

Science

Influenza InfectionImmunologyUniversal ProtectionStrain SelectionMultidomain Antibody +17

The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis

Maarten Van Roy, Cedric Ververken, Els Beirnaert, +11

Arthritis Research & Therapy

InflammationRheumatologyRheumatoid DisorderAnti-inflammatoryAutoimmune Disease +8

Nanobodies Targeting the Hepatocyte Growth Factor: Potential New Drugs for Molecular Cancer Therapy

Maria J.W.D. Vosjan, Jo Vercammen, Joost A. Kolkman, +3

Molecular Cancer Therapeutics

NanoparticlesNanotherapeuticsEngineeringTumor Growth DelayPotential New Drugs +27

Nanobodies – from llamas to therapeutic proteins

Joost A. Kolkman, Debbie A. Law

Drug Discovery Today Technologies

NanomedicineEngineeringNano-drug DeliveryTherapeutic ProteinsProtein Nanoparticles +1

Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction

Heather Huet, Joseph D. Growney, Jennifer Johnson, +18

mAbs

NanotherapeuticsEngineeringImmunologyCell DeathImmunotherapeutics +23

Factor VIII-Factor IX Interactions: Molecular Sites Involved in Enzyme-Cofactor Complex Assembly

Patrick H. N. Celie, Joost A. Kolkman, Peter J. Lenting, +1

Thrombosis and Haemostasis

Protein AssemblyMolecular BiologyMolecular SitesEnzyme-cofactor Complex AssemblyProtein Expression +14

Regions 301–303 and 333–339 in the catalytic domain of blood coagulation Factor IX are Factor VIII-interactive sites involved in stimulation of enzyme activity

Joost A. Kolkman, Peter J. Lenting, Koen Mertens

Biochemical Journal

On the two iron centers of desulfoferrodoxin

Marc F. J. M. Verhagen, W.G.B. Voorhorst, Joost A. Kolkman, +2

FEBS Letters

Blood Coagulation Factor IX Residues Glu78 and Arg94 Provide a Link between Both Epidermal Growth Factor-like Domains That Is Crucial in the Interaction with Factor VIII Light Chain

Olivier D. Christophe, Peter J. Lenting, Joost A. Kolkman, +2

Journal of Biological Chemistry