Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

Liping Su, Le Shen, Daniel Clayburgh, +5

Gastroenterology

InflammationChronic Inflammatory DiseasesMucosal ImmunologyImmunologyGastroenterology +7

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

Liping Su, Sam C. Nalle, Le Shen, +9

Gastroenterology

InflammationSignal TransductionImmunologyChronic InflammationCell Death +8

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

Christopher R. Weber, Sam C. Nalle, Maria Tretiakova, +2

Laboratory Investigation

InflammationAutoimmune DiseaseEarly Neoplastic TransformationImmunologyGastroenterology +7

Molecular correlates differentiate response to atezolizumab (atezo) + bevacizumab (bev) vs sunitinib (sun): Results from a phase III study (IMmotion151) in untreated metastatic renal cell carcinoma (mRCC)

Brian I. Rini, Mahrukh Huseni, Michael B. Atkins, +14

Annals of Oncology

UrologyGenitourinary CancerMedicineMolecular CorrelatesVs Sunitinib +7

Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability

Sam C. Nalle, Li Zuo, Ma. Lora Drizella M. Ong, +10

Journal of Clinical Investigation

ImmunologyGastroenterologyPathologyDigestive TractImmunotherapy +15

Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease

Sam C. Nalle, Heewon Kwak, Karen L. Edelblum, +6

Science Translational Medicine

FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody–Drug Conjugates

Byoung-Chul Lee, Cécile Chalouni, Sophia Doll, +8

Bioconjugate Chemistry

Fret AssayPeptide EngineeringImmunologyPeptide TherapeuticsPeptide Chemistry +16

Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation

Sam C. Nalle, Rosa Barreira da Silva, Hua Zhang, +12

PLoS ONE

Ménétrier’s Disease Therapy: Rebooting Mucosal Signaling

Sam C. Nalle, Jerrold R. Turner

Science Translational Medicine

InflammationSignal TransductionDisease MechanismRare Hyperproliferative DisorderGastrointestinal Pharmacology +10